Would this be in a different way to the equivalent JavaScript code? Or do you just mean like physically, the layout of the code with the additional TypeScript syntax makes it appear more nested/indented and more difficult to parse?

TS doesn't really do any worse than JS in this respect; the key here is the difference between either of them and Python.

Ah, this is a facepalm moment in that I had completely misread the initial comment not as being a comparison of JS/TS to python, but of JS to TS then a further comparison to python. Now it makes much more sense!